The Effects of Curcumin on NF-κB Level and Degree of Liver Fibrosis in Rat Liver Fibrosis

• Main Authors: Supriono, Bogi Pratomo, Dedy Indra Praja
• Format: Article
• Language: Indonesian
• Published: Department of Internal Medicine, Faculty of Medicine Universitas Indonesia-Cipto Mangunkusumo Hospital 2018-12-01
• Series: Jurnal Penyakit Dalam Indonesia
• Subjects: Animal model of liver fibrosis; Curcumin; Degree of liver fibrosis; NF-κB
• Online Access: http://jurnalpenyakitdalam.ui.ac.id/index.php/jpdi/article/view/271/168
• ISSN: 2406-8969; 2549-0621

Introduction. Chronic inflammation is the main mechanism responsible for liver fibrosis. NF-κB regulates inflammation, wound healing, and cell death. Curcumin acts as an antiinflammatory, antifibrotic and induced apoptosis, one of them through resistance to NF-κB. This study aimed to determine the effect of curcumin on NF-κB levels and the correlation between the duration of curcumin on NF-κB and degree of liver fibrosis. Methods. This study was an experimental in rats using a completely randomized design. The treatment of rats was induced with CCl4 and given curcumin. Measurement of NF-κB levels by ELISA method. Degree of liver fibrosis using metavir scoring system. The data were analyzed using correlation test, one-way anova, unpair T-test, mann-whitney, chi-square, kruskal-wallis, structural model with significant p value p < 0,05. Results. There were significant differences in NF-κB level and degree of liver fibrosis between the positive control group and the negative control group. There was a significant effect of curcumin administration on the level of NF-κB and degree of liver fibrosis. There was a negative correlation between duration of curcumin and NF-κB level and positive correlationbetween NF-κB levels and degree of liver fibrosis. Conclusions. Curcumin can decrease NF-κB levels and decrease the degree of liver fibrosis. The duration of the curcumin administration correlated with decreased levels of NF-κB and decreased NF-κB levels correlated with decreased degree of liver fibrosis in rat liver fibrosis.