Hemostatic Parameters according to Renal Function and Time after Transplantation in Brazilian Renal Transplanted Patients

• Main Authors: Ana Paula Lucas Mota, Patrícia Nessralla Alpoim, Roberta Carvalho de Figueiredo, Ana Cristina Simões e Silva, Karina Braga Gomes, Luci Maria SantAna Dusse
• Format: Article
• Language: English
• Published: Hindawi Limited 2015-01-01
• Series: Disease Markers
• Online Access: http://dx.doi.org/10.1155/2015/472750

Kidney transplantation is the key for patients with end-stage renal disease, improving quality of life and longer survival. However, kidney transplant triggers an intense inflammatory response and alters the hemostatic system, but the pathophysiological mechanisms of these changes are not completely understood. The aim of this cross-sectional cohort study was to investigate hemostatic biomarkers in Brazilian renal transplanted patients according to renal function and time after transplantation. A total of 159 renal transplanted patients were enrolled and D-Dimer (D-Di), Thrombomodulin (TM), von Willebrand Factor (VWF), and ADAMTS13 plasma levels were assessed by ELISA. An increase of D-Di was observed in patients with higher levels of creatinine. ADAMTS13 levels were associated with creatinine plasma levels and D-Di levels with Glomerular Filtration Rate. These results suggested that D-Di and ADAMTS13 can be promising markers to estimate renal function. ADAMTS13 should be investigated throughout the posttransplant time to clarify the participation of this enzyme in glomerular filtration and acceptance or rejection of the graft in Brazilian transplanted patients.