Recent progress in the discovery of small molecules for the treatment of amyotrophic lateral sclerosis (ALS)

Recent progress in the discovery of small molecules for the treatment of amyotrophic lateral sclerosis (ALS)

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder with few therapeutic options. While several gene mutations have been implicated in ALS, the exact cause of neuronal dysfunction is unknown and motor neurons of affected individuals display numerous cellular abnormalities. Ongo...

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Bibliographic Details
Main Authors: Allison S. Limpert, Margrith E. Mattmann, Nicholas D. P. Cosford
Format: Article
Language:English
Published: Beilstein-Institut 2013-04-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
amyotrophic lateral sclerosis (ALS)
copper/zinc (Cu-Zn) superoxide dismutase 1 (SOD1)
glutamate toxicity
neurodegeneration
oxidative stress
Online Access:https://doi.org/10.3762/bjoc.9.82

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