ADAM10 and ADAM17 cleave PD-L1 to mediate PD-(L)1 inhibitor resistance

ADAM10 and ADAM17 cleave PD-L1 to mediate PD-(L)1 inhibitor resistance

ADAM10 and ADAM17 expression and soluble PD-L1 (sPD-L1) predict poor prognosis in many malignancies, including in patients treated with PD-(L)1 inhibitors. The mechanism of soluble PD-L1 production and its effects are unknown. Here we uncover a novel mechanism of ADAM10- and ADAM17-mediated resistan...

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Bibliographic Details
Main Authors: Jacob J. Orme, Khalid A. Jazieh, Tiancheng Xie, Susan Harrington, Xin Liu, Matthew Ball, Benjamin Madden, M. Cristine Charlesworth, Tariq U. Azam, Fabrice Lucien, Bharath Wootla, Yanli Li, Jose Caetano Villasboas, Aaron S. Mansfield, Roxana S. Dronca, Haidong Dong
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:OncoImmunology
Subjects:
pd-1 resistance
checkpoint inhibitor resistance
spd-l1
adam10
adam17
Online Access:http://dx.doi.org/10.1080/2162402X.2020.1744980

Internet

http://dx.doi.org/10.1080/2162402X.2020.1744980

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