Facile synthesis and in vitro anticancer evaluation of a new series of tetrahydroquinoline

Facile synthesis and in vitro anticancer evaluation of a new series of tetrahydroquinoline

Tetrahydroquinoline (THQ) is an important structure for synthesizing multiple biologically active derivatives. Thus, we developed new quinoline derivatives and investigated them as anticancer agents. First, infrared spectroscopy, nuclear magnetic resonance spectroscopy, and other techniques were use...

Full description

Bibliographic Details
Main Authors:	Usama Fathy, Hayam A. Abd El Salam, Eman A. Fayed, Abdelbaset M. Elgamal, Ahmed Gouda
Format:	Article
Language:	English
Published:	Elsevier 2021-10-01
Series:	Heliyon
Subjects:	Tetrahydroquinoline Quinolone Pyrazole Isooxazole Isatin Anticancer activity
Online Access:	http://www.sciencedirect.com/science/article/pii/S2405844021022209

Similar Items

N-[(9-Ethyl-9H-carbazol-3-yl)methylene]-3,4-dimethylisoxazol-5-amine
by: Abdullah Mohamed Asiri, et al.
Published: (2010-05-01)

Synthesis of Novel <i>Spiro</i>-Tetrahydroquinoline Derivatives and Evaluation of Their Pharmacological Effects on Wound Healing
by: Yan-Cheng Liou, et al.
Published: (2021-06-01)

Synthesis and Bioactivity Assessment of Novel Spiro Pyrazole-Oxindole Congeners Exhibiting Potent and Selective <i>in vitro</i> Anticancer Effects
by: Heba M. Abo-Salem, et al.
Published: (2020-03-01)

Palladium-catalyzed picolinamide-directed iodination of remote ortho-C−H bonds of arenes: Synthesis of tetrahydroquinolines
by: William A. Nack, et al.
Published: (2016-06-01)

Crystal structure of 1-[(2S*,4R*)-6-fluoro-2-methyl-1,2,3,4-tetrahydroquinolin-4-yl]pyrrolidin-2-one
by: P. S. Pradeep, et al.
Published: (2014-09-01)

Facile synthesis of functionalized tetrahydroquinolines via domino Povarov reactions of arylamines, methyl propiolate and aromatic aldehydes
by: Jing Sun, et al.
Published: (2012-10-01)

Experimental and Theoretical Approaches in the Study of Phenanthroline‐Tetrahydroquinolines for Alzheimer's Disease
by: Dr. Yorley Duarte, et al.
Published: (2019-05-01)

A One-Pot Divergent Sequence to Pyrazole and Quinoline Derivatives
by: Guido Gambacorta, et al.
Published: (2020-05-01)

Crystal structure of 1-methanesulfonyl-1,2,3,4-tetrahydroquinoline
by: S. Jeyaseelan, et al.
Published: (2015-01-01)

Synthesis, antimicrobial, anticancer, antiviral evaluation and QSAR studies of 4-(1-aryl-2-oxo-1,2-dihydro-indol-3-ylideneamino)-N-substituted benzene sulfonamides
by: Mahesh Kumar, et al.
Published: (2014-09-01)

Crystal structure of cis-1-(2-methyl-1,2,3,4-tetrahydroquinolin-4-yl)azepan-2-one
by: P. S. Pradeep, et al.
Published: (2014-09-01)

Efficient synthesis and antioxidant activity of novel N-propargyl tetrahydroquinoline derivatives through the cationic Povarov reaction
by: Yeray A. Rodriguez Núñez, et al.
Published: (2019-08-01)

Crystal structure of 1-benzylsulfonyl-1,2,3,4-tetrahydroquinoline
by: S. Jeyaseelan, et al.
Published: (2015-04-01)

(2<i>S*</i>,4<i>S*</i>)-4-[(<i>E</i>)-(2,2-Dimethylhydrazono)methyl]-6-methoxy-4-methyl-2-[(<i>E</i>)-styryl]-1,2,3,4-tetrahydroquinoline
by: José Clerigué, et al.
Published: (2021-06-01)

Biological Properties of New Chiral 2-Methyl-5,6,7,8-tetrahydroquinolin-8-amine-based Compounds
by: Giorgio Facchetti, et al.
Published: (2020-11-01)

Novel 4-ferrocenyl-8-(phenylthio)-1,2,3,4-tetrahydroquinoline: Design, synthesis and spectral characterization
by: Minić Aleksandra, et al.
Published: (2019-01-01)

Synthesis and in vitro cytotoxicity evaluation of isatin-pyrrole derivatives against HepG2 cell line
by: Santoso Mardi, et al.
Published: (2021-02-01)

Anticancer Compounds Based on Isatin-Derivatives: Strategies to Ameliorate Selectivity and Efficiency
by: Raphael Enoque Ferraz de Paiva, et al.
Published: (2021-02-01)

“Indole” a versatile nucleus in pharmaceutical field.
by: Babasaheb Zine, et al.
Published: (2020-08-01)

“Indole” a versatile nucleus in pharmaceutical field.
by: Babasaheb Zine, et al.
Published: (2020-08-01)

The Role of the Conjugate Bridge in Electronic Structures and Related Properties of Tetrahydroquinoline for Dye Sensitized Solar Cells
by: You-Zhi Wu, et al.
Published: (2013-03-01)

Synthesis of novel tetrahydroquinoline derivatives from α,α′-bis(substituted-benzylidene)cycloalkanones
by: Enayatollah Sheikhhosseini, et al.
Published: (2016-09-01)

Crystal structure of 1-[(6-chloropyridin-3-yl)sulfonyl]-1,2,3,4-tetrahydroquinoline
by: S. Jeyaseelan, et al.
Published: (2015-06-01)

Biological Validation of Novel Polysubstituted Pyrazole Candidates with in Vitro Anticancer Activities
by: Hoda H. Fahmy, et al.
Published: (2016-02-01)

Synthesis, characterization and anticancer studies of new steroidal oxadiazole, pyrrole and pyrazole derivatives
by: Shamsuzzaman, et al.
Published: (2015-07-01)

Mechanochemical Aza-Vinylogous Povarov Reactions for the Synthesis of Highly Functionalized 1,2,3,4-Tetrahydroquinolines and 1,2,3,4-Tetrahydro-1,5-Naphthyridines
by: José Clerigué, et al.
Published: (2021-03-01)

Modifications on the Tetrahydroquinoline Scaffold Targeting a Phenylalanine Cluster on GPER as Antiproliferative Compounds against Renal, Liver and Pancreatic Cancer Cells
by: David Méndez-Luna, et al.
Published: (2021-01-01)

Design, synthesis, in vitro anticancer evaluation, kinase inhibitory effects, and pharmacokinetic profile of new 1,3,4-triarylpyrazole derivatives possessing terminal sulfonamide moiety
by: Mohammed S. Abdel-Maksoud, et al.
Published: (2019-01-01)

Protective Effect of Tetrahydroquinolines from the Edible Insect <i>Allomyrina dichotoma </i>on LPS-Induced Vascular Inflammatory Responses
by: InWha Park, et al.
Published: (2020-05-01)

Novel Anticancer Fused Pyrazole Derivatives as EGFR and VEGFR-2 Dual TK Inhibitors
by: Nashwa M. Saleh, et al.
Published: (2020-01-01)

One-Pot Multicomponent Synthesis and Bioevaluation of Tetrahydroquinoline Derivatives as Potential Antioxidants, α-Amylase Enzyme Inhibitors, Anti-Cancerous and Anti-Inflammatory Agents
by: Samra Farooq, et al.
Published: (2020-06-01)

Synthesis and Crystal Structure of Two Nitro-Regioisomers of cis-4(4- Methoxyphenyl)-3-Methyl-2-Phenyl-1,2,3,4-Tetrahydroquinoline
by: Arnold R. Romero Bohórquez, et al.
Published: (2013-04-01)

Flavouring Group Evaluation 34: One tetrahydroquinoline derivative from chemical group 28 ‐ Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC)
by: European Food Safety Authority (EFSA)
Published: (2008-08-01)

The green synthesis of N-hydroxyethyl-substituted 1,2,3,4-tetrahydroquinolines with acidic ionic liquid as catalyst
by: Guo Hui, et al.
Published: (2020-10-01)

Synthesis, antimicrobial, anticancer, antiviral evaluation and QSAR studies of 4-(1-aryl-2-oxo-1,2-dihydro-indol-3-ylideneamino)-N-substituted benzene sulfonamides
by: Clercq, E.D, et al.
Published: (2014)

An updated review on Couroupita guianensis Aubl: a sacred plant of India with myriad medicinal properties
by: Lawrence Anna Sheba, et al.
Published: (2020-01-01)

1,7-Sigmatropic rearrangement in 1,2-dihydro and 1,2,3,4-tetrahydroquinoline synthesis using marine sponge/H2C2O4 as a catalyst
by: Mohammad Reza Shushizadeh, et al.
Published: (2015-11-01)

Suppression of Pax3–MITF-M Axis Protects from UVB-Induced Skin Pigmentation by Tetrahydroquinoline Carboxamide
by: Yong-Pyo Choi, et al.
Published: (2020-12-01)

Facile Synthesis of 5, 6, 7, 8-Tetrahydropyrimido [4, 5-b]-quinoline Derivatives
by: Mohamed Abdelhamed Morsy, et al.
Published: (2006-11-01)

Simple preparation of new N-(6-methyl-2-nitrophenyl-1,2,3,4- tetrahydroquinolin-4-yl) pyrrolidin-2-ones and their spectroscopic analysis
by: John H. Bermúdez, et al.
Published: (2011-08-01)