The Effect of Deflazacort Treatment on the Functioning of Skeletal Muscle Mitochondria in Duchenne Muscular Dystrophy

The Effect of Deflazacort Treatment on the Functioning of Skeletal Muscle Mitochondria in Duchenne Muscular Dystrophy

Duchenne muscular dystrophy (DMD) is a severe hereditary disease caused by a lack of dystrophin, a protein essential for myocyte integrity. Mitochondrial dysfunction is reportedly responsible for DMD. This study examines the effect of glucocorticoid deflazacort on the functioning of the skeletal-mus...

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Bibliographic Details
Main Authors: Mikhail V. Dubinin, Eugeny Yu. Talanov, Kirill S. Tenkov, Vlada S. Starinets, Natalia V. Belosludtseva, Konstantin N. Belosludtsev
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:International Journal of Molecular Sciences
Subjects:
Duchenne muscular dystrophy
skeletal muscle
deflazacort
mitochondria
Ca2+ uniporter
mitochondrial permeability transition
Online Access:https://www.mdpi.com/1422-0067/21/22/8763

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