Quercetin-Conjugated Superparamagnetic Iron Oxide Nanoparticles Protect AlCl3-Induced Neurotoxicity in a Rat Model of Alzheimer’s Disease via Antioxidant Genes, APP Gene, and miRNA-101

Quercetin-Conjugated Superparamagnetic Iron Oxide Nanoparticles Protect AlCl3-Induced Neurotoxicity in a Rat Model of Alzheimer’s Disease via Antioxidant Genes, APP Gene, and miRNA-101

Alzheimer’s disease (AD) is a neurodegenerative disease with cognitive impairment. Oxidative stress in neurons is considered as a reason for development of AD. Antioxidant agents such as quercetin slow down AD progression, but the usage of this flavonoid has limitations because of its low bioavailab...

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Bibliographic Details
Main Authors: Elnaz Amanzadeh Jajin, Abolghasem Esmaeili, Soheila Rahgozar, Maryam Noorbakhshnia
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Neuroscience
Subjects:
Alzheimer’s disease
AlCl3
quercetin
miR-101
superparamagnetic iron oxide nanoparticle
antioxidant
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2020.598617/full

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