Advances in research on pharmacotherapy of sarcopenia

• Main Authors: Yang Feike, Liu Zhijie, Chen Wei
• Format: Article
• Language: English
• Published: Wiley 2021-09-01
• Series: Aging Medicine
• Subjects: aging; muscle wasting; pathogenesis; pharmacotherapy; sarcopenia; signaling
• Online Access: https://doi.org/10.1002/agm2.12168

Abstract Sarcopenia is a comprehensive degenerative disease with the progressive loss of skeletal muscle mass with age, accompanied by the loss of muscle strength and muscle dysfunction. As a new type of senile syndrome, sarcopenia seriously threatens the health of the elderly. The first‐line treatment for sarcopenia is exercise and nutritional supplements. However, pharmacotherapy will provide more reliable and sustainable interventions in geriatric medicine. Clinical trials of new drugs targeting multiple molecules are ongoing. This article focuses on the latest progress in pharmacotherapeutic approaches of sarcopenia in recent years by comprehensively reviewing the clinical outcomes of the existing and emerging pharmacotherapies as well as the molecular mechanisms underlying their therapeutic benefits and side effects.