A Steric “Ball-and-Chain” Mechanism for pH-Mediated Regulation of Gap Junction Channels

A Steric “Ball-and-Chain” Mechanism for pH-Mediated Regulation of Gap Junction Channels

Summary: Gap junction channels (GJCs) mediate intercellular communication and are gated by numerous conditions such as pH. The electron cryomicroscopy (cryo-EM) structure of Cx26 GJC at physiological pH recapitulates previous GJC structures in lipid bilayers. At pH 6.4, we identify two conformationa...

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Bibliographic Details
Main Authors:	Ali K. Khan, Maciej Jagielnicki, William E. McIntire, Michael D. Purdy, Venkatasubramanian Dharmarajan, Patrick R. Griffin, Mark Yeager
Format:	Article
Language:	English
Published:	Elsevier 2020-04-01
Series:	Cell Reports
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211124720303600

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