Absence of the kinase S6k1 mimics the effect of chronic endurance exercise on glucose tolerance and muscle oxidative stress

Absence of the kinase S6k1 mimics the effect of chronic endurance exercise on glucose tolerance and muscle oxidative stress

Objective: Ribosomal protein S6 Kinase-1 (S6K1) has been linked to resistance exercise-mediated improvements in glycemia. We hypothesized that S6K1 may also play a role in regulating glycemic control in response to endurance exercise training. Methods: S6k1-knockout (S6K1KO) and WT mice on a 60 cal%...

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Bibliographic Details
Main Authors: C. Binsch, T. Jelenik, A. Pfitzer, M. Dille, S. Müller-Lühlhoff, S. Hartwig, S. Karpinski, S. Lehr, D.G. Kabra, A. Chadt, M. Roden, H. Al-Hasani, T.R. Castañeda
Format: Article
Language:English
Published: Elsevier 2017-11-01
Series:Molecular Metabolism
Subjects:
S6K1
Exercise
Glycemic control
Metabolic phenotyping
Reactive oxidative species
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877817305422

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