Stability analysis of a viral infection dynamics model with infection age of cells and general saturated infection rate

In order to understand the viral dynamics processes inclucding infection, duplicate, eliminate, etc. in human body, a viral infection model with infection age of cells and general saturated infection rate is investigated. It is proved that the model has a unique infected steady state when the basic...

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Bibliographic Details
Main Authors: Liangchen LI, Rui XU
Format: Article
Language:zho
Published: Hebei University of Science and Technology 2016-08-01
Series:Journal of Hebei University of Science and Technology
Subjects:
Online Access:http://xuebao.hebust.edu.cn/hbkjdx/ch/reader/create_pdf.aspx?file_no=b201604006&flag=1&journal_
Description
Summary:In order to understand the viral dynamics processes inclucding infection, duplicate, eliminate, etc. in human body, a viral infection model with infection age of cells and general saturated infection rate is investigated. It is proved that the model has a unique infected steady state when the basic reproduction ratio is greater than one unity. By analyzing the characteristic of relevant equations, the local stability of effective steady state is dislussed. By using suitable Lyapunov functional and LaSalle’s invariance principle, it is proved that when the basic reproduction ratio is less than one unity, the infection-free steady state is globally asymptotically stable; and when the basic reproduction ratio is greater than one unity, the infected steady state is globally asymptotically stable.
ISSN:1008-1542