High-Altitude Cognitive Impairment Is Prevented by Enriched Environment Including Exercise via VEGF Signaling

High-Altitude Cognitive Impairment Is Prevented by Enriched Environment Including Exercise via VEGF Signaling

Exposure to hypobaric hypoxia at high altitude (above 2500 m asl) causes cognitive impairment, mostly attributed to changes in brain perfusion and consequently neuronal death. Enriched environment and voluntary exercise has been shown to improve cognitive function, to enhance brain microvasculature...

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Bibliographic Details
Main Authors: Christina Koester-Hegmann, Harkaitz Bengoetxea, Dmitry Kosenkov, Markus Thiersch, Thomas Haider, Max Gassmann, Edith M. Schneider Gasser
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Cellular Neuroscience
Subjects:
neuroprotection
neurogenesis
angiogenesis
tyrosine kinase inhibitor
spatial memory
visual memory
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2018.00532/full

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