The unfolded protein response and its potential role in Huntington ́s disease elucidated by a systems biology approach [v1; ref status: indexed, http://f1000r.es/59e]

The unfolded protein response and its potential role in Huntington ́s disease elucidated by a systems biology approach [v1; ref status: indexed, http://f1000r.es/59e]

Huntington ́s disease (HD) is a progressive, neurodegenerative disease with a fatal outcome. Although the disease-causing gene (huntingtin) has been known for over 20 years, the exact mechanisms leading to neuronal cell death are still controversial. One potential mechanism contributing to the massi...

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Bibliographic Details
Main Authors: Ravi Kiran Reddy Kalathur, Joaquin Giner-Lamia, Susana Machado, Kameshwar R S Ayasolla, Matthias E. Futschik
Format: Article
Language:English
Published: F1000 Research Ltd 2015-05-01
Series:F1000Research
Subjects:
Motor Systems
Movement Disorders
Neuromuscular Diseases
Online Access:http://f1000research.com/articles/4-103/v1

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