Immunization with a hemagglutinin-derived synthetic peptide formulated with a CpG-DNA-liposome complex induced protection against lethal influenza virus infection in mice.

Immunization with a hemagglutinin-derived synthetic peptide formulated with a CpG-DNA-liposome complex induced protection against lethal influenza virus infection in mice.

Whole-virus vaccines, including inactivated or live-attenuated influenza vaccines, have been conventionally developed and supported as a prophylaxis. These currently available virus-based influenza vaccines are widely used in the clinic, but the vaccine production takes a long time and a huge number...

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Main Authors: Jae Won Rhee, Dongbum Kim, Byung Kwon Park, Sanghoon Kwon, Sunhee Cho, Ilseob Lee, Man-Seong Park, Jae-Nam Seo, Yong-Sun Kim, Hong Seok Choi, Younghee Lee, Hyung-Joo Kwon
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3492448?pdf=render

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