Skeleton-Controlled pDNA Delivery of Renewable Steroid-Based Cationic Lipids, the Endocytosis Pathway Analysis and Intracellular Localization

Skeleton-Controlled pDNA Delivery of Renewable Steroid-Based Cationic Lipids, the Endocytosis Pathway Analysis and Intracellular Localization

Using renewable and biocompatible natural-based resources to construct functional biomaterials has attracted great attention in recent years. In this work, we successfully prepared a series of steroid-based cationic lipids by integrating various steroid skeletons/hydrophobes with (l-)-arginine headg...

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Bibliographic Details
Main Authors: Ruilong Sheng, Zhao Wang, Ting Luo, Amin Cao, Jingjing Sun, Joseph M. Kinsella
Format: Article
Language:English
Published: MDPI AG 2018-01-01
Series:International Journal of Molecular Sciences
Subjects:
steroid
gene delivery
serum-compatible
structure–function relationships
endocytosis pathway
Online Access:http://www.mdpi.com/1422-0067/19/2/369

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