High C-reactive protein level is associated with high-risk adenoma

Background/Aims: There is substantial evidence supporting a role of inflammation in the pathogenesis of colorectal cancer; however, little is known about the association between serum C-reactive protein (CRP) and the risk of colorectal adenoma. This study was conducted to investigate the association...

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Main Authors: Hyae Min Lee, Jae Myung Cha, Jung Lok Lee, Jung Won Jeon, Hyun Phil Shin, Kwang Ro Joo, Jin Young Yoon, Joung Il Lee
Format: Article
Language:English
Published: Korean Association for the Study of Intestinal Diseases 2017-10-01
Series:Intestinal Research
Subjects:
Online Access:https://doi.org/10.5217/ir.2017.15.4.511
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spelling doaj-d13f5e6d9224498989e08da170d82af22020-11-25T02:40:41ZengKorean Association for the Study of Intestinal DiseasesIntestinal Research1598-91002017-10-0115451151710.5217/ir.2017.15.4.511ir.2017.15.4.511High C-reactive protein level is associated with high-risk adenomaHyae Min Lee0Jae Myung Cha1Jung Lok Lee2Jung Won Jeon3Hyun Phil Shin4Kwang Ro Joo5Jin Young Yoon6Joung Il Lee7Department of Internal Medicine, Kyung Hee University Hospital at Gangdong, Kyung Hee University School of Medicine, Seoul, Korea.Department of Internal Medicine, Kyung Hee University Hospital at Gangdong, Kyung Hee University School of Medicine, Seoul, Korea.Department of Internal Medicine, Kyung Hee University Hospital at Gangdong, Kyung Hee University School of Medicine, Seoul, Korea.Department of Internal Medicine, Kyung Hee University Hospital at Gangdong, Kyung Hee University School of Medicine, Seoul, Korea.Department of Internal Medicine, Kyung Hee University Hospital at Gangdong, Kyung Hee University School of Medicine, Seoul, Korea.Department of Internal Medicine, Kyung Hee University Hospital at Gangdong, Kyung Hee University School of Medicine, Seoul, Korea.Department of Internal Medicine, Kyung Hee University Hospital at Gangdong, Kyung Hee University School of Medicine, Seoul, Korea.Department of Internal Medicine, Kyung Hee University Hospital at Gangdong, Kyung Hee University School of Medicine, Seoul, Korea.Background/Aims: There is substantial evidence supporting a role of inflammation in the pathogenesis of colorectal cancer; however, little is known about the association between serum C-reactive protein (CRP) and the risk of colorectal adenoma. This study was conducted to investigate the association between serum CRP and colorectal adenoma risk.Methods: A retrospective cross-sectional study was performed on first-time screening colonoscopies in asymptomatic subjects who also had their serum CRP level measured during a routine health check-up between September 2006 and September 2009 in Korea. Serum CRP level was compared between high-risk and low-risk adenoma groups and independent predictors of high-risk adenoma were analyzed using multivariate regression analysis.Results: Among the 3,309 eligible patients, the high-risk adenoma group had higher serum CRP levels than the low-risk adenoma group (P=0.000). In addition, patients with a high-risk adenoma were more frequently included in the high CRP group than in the low CRP group (8.6% vs. 4.0%, P<0.001). The prevalence of high-risk adenoma was 3.5 times higher in the highest quartile of CRP level (P=0.000) compared with that in the lowest quartile. In logistic regression analysis, a higher quartile CRP level was found to be an independent risk factor for high-risk adenoma (odds ratio, 1.8; 95% confidence interval, 1.3–2.5; P=0.000).Conclusions: High CRP level is associated with high-risk adenoma in both men and women. Our data may support the association between chronic inflammation and colorectal neoplasia, which warrants further investigation.https://doi.org/10.5217/ir.2017.15.4.511ColonInflammationNeoplasmsC-reactive proteinColonoscopy
collection DOAJ
language English
format Article
sources DOAJ
author Hyae Min Lee
Jae Myung Cha
Jung Lok Lee
Jung Won Jeon
Hyun Phil Shin
Kwang Ro Joo
Jin Young Yoon
Joung Il Lee
spellingShingle Hyae Min Lee
Jae Myung Cha
Jung Lok Lee
Jung Won Jeon
Hyun Phil Shin
Kwang Ro Joo
Jin Young Yoon
Joung Il Lee
High C-reactive protein level is associated with high-risk adenoma
Intestinal Research
Colon
Inflammation
Neoplasms
C-reactive protein
Colonoscopy
author_facet Hyae Min Lee
Jae Myung Cha
Jung Lok Lee
Jung Won Jeon
Hyun Phil Shin
Kwang Ro Joo
Jin Young Yoon
Joung Il Lee
author_sort Hyae Min Lee
title High C-reactive protein level is associated with high-risk adenoma
title_short High C-reactive protein level is associated with high-risk adenoma
title_full High C-reactive protein level is associated with high-risk adenoma
title_fullStr High C-reactive protein level is associated with high-risk adenoma
title_full_unstemmed High C-reactive protein level is associated with high-risk adenoma
title_sort high c-reactive protein level is associated with high-risk adenoma
publisher Korean Association for the Study of Intestinal Diseases
series Intestinal Research
issn 1598-9100
publishDate 2017-10-01
description Background/Aims: There is substantial evidence supporting a role of inflammation in the pathogenesis of colorectal cancer; however, little is known about the association between serum C-reactive protein (CRP) and the risk of colorectal adenoma. This study was conducted to investigate the association between serum CRP and colorectal adenoma risk.Methods: A retrospective cross-sectional study was performed on first-time screening colonoscopies in asymptomatic subjects who also had their serum CRP level measured during a routine health check-up between September 2006 and September 2009 in Korea. Serum CRP level was compared between high-risk and low-risk adenoma groups and independent predictors of high-risk adenoma were analyzed using multivariate regression analysis.Results: Among the 3,309 eligible patients, the high-risk adenoma group had higher serum CRP levels than the low-risk adenoma group (P=0.000). In addition, patients with a high-risk adenoma were more frequently included in the high CRP group than in the low CRP group (8.6% vs. 4.0%, P<0.001). The prevalence of high-risk adenoma was 3.5 times higher in the highest quartile of CRP level (P=0.000) compared with that in the lowest quartile. In logistic regression analysis, a higher quartile CRP level was found to be an independent risk factor for high-risk adenoma (odds ratio, 1.8; 95% confidence interval, 1.3–2.5; P=0.000).Conclusions: High CRP level is associated with high-risk adenoma in both men and women. Our data may support the association between chronic inflammation and colorectal neoplasia, which warrants further investigation.
topic Colon
Inflammation
Neoplasms
C-reactive protein
Colonoscopy
url https://doi.org/10.5217/ir.2017.15.4.511
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