Dopaminergic neuronal differentiation from the forebrain-derived human neural stem cells induced in cultures by using a combination of BMP-7 and pramipexole with growth factors

Dopaminergic neuronal differentiation from the forebrain-derived human neural stem cells induced in cultures by using a combination of BMP-7 and pramipexole with growth factors

Transplantation of dopaminergic (DA) neurons is considered to be the most promising therapeutic strategy for replacing degenerated dopamine cells in the midbrain of Parkinson’s disease (PD), thereby restoring normal neural circuit function and slow clinical progression of the disease. Human neural s...

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Bibliographic Details
Main Authors: Hongna eYang, Jing eWang, Feng eWang, Xiaodun eLiu, Heng eChen, WeiMing eDuan, Tingyu eQu
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-04-01
Series:Frontiers in Neural Circuits
Subjects:
Th
Dopamine release
BMP-7
PRX
dopamiergic neurons
forebrain-derived neural stem cells
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncir.2016.00029/full

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