Retinal transplantation of photoreceptors results in donor–host cytoplasmic exchange

Retinal transplantation of photoreceptors results in donor–host cytoplasmic exchange

Integration of transplanted photoreceptors into the host retina has been assumed as the underlying mechanism for vision improvement in pre-clinical studies. Here, the authors show that the majority of transplanted photoreceptors do not structurally integrate but exchange intercellular material with...

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Main Authors: Tiago Santos-Ferreira, Sílvia Llonch, Oliver Borsch, Kai Postel, Jochen Haas, Marius Ader
Format: Article
Language:English
Published: Nature Publishing Group 2016-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms13028
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spelling doaj-d130eae8679243cab91029177e74c7b82021-05-11T11:20:20ZengNature Publishing GroupNature Communications2041-17232016-10-01711710.1038/ncomms13028Retinal transplantation of photoreceptors results in donor–host cytoplasmic exchangeTiago Santos-Ferreira0Sílvia Llonch1Oliver Borsch2Kai Postel3Jochen Haas4Marius Ader5CRTD/Center for Regenerative Therapies Dresden, Technische Universität DresdenCRTD/Center for Regenerative Therapies Dresden, Technische Universität DresdenCRTD/Center for Regenerative Therapies Dresden, Technische Universität DresdenCRTD/Center for Regenerative Therapies Dresden, Technische Universität DresdenCRTD/Center for Regenerative Therapies Dresden, Technische Universität DresdenCRTD/Center for Regenerative Therapies Dresden, Technische Universität DresdenIntegration of transplanted photoreceptors into the host retina has been assumed as the underlying mechanism for vision improvement in pre-clinical studies. Here, the authors show that the majority of transplanted photoreceptors do not structurally integrate but exchange intercellular material with host cells.https://doi.org/10.1038/ncomms13028
collection DOAJ
language English
format Article
sources DOAJ
author Tiago Santos-Ferreira
Sílvia Llonch
Oliver Borsch
Kai Postel
Jochen Haas
Marius Ader
spellingShingle Tiago Santos-Ferreira
Sílvia Llonch
Oliver Borsch
Kai Postel
Jochen Haas
Marius Ader
Retinal transplantation of photoreceptors results in donor–host cytoplasmic exchange
Nature Communications
author_facet Tiago Santos-Ferreira
Sílvia Llonch
Oliver Borsch
Kai Postel
Jochen Haas
Marius Ader
author_sort Tiago Santos-Ferreira
title Retinal transplantation of photoreceptors results in donor–host cytoplasmic exchange
title_short Retinal transplantation of photoreceptors results in donor–host cytoplasmic exchange
title_full Retinal transplantation of photoreceptors results in donor–host cytoplasmic exchange
title_fullStr Retinal transplantation of photoreceptors results in donor–host cytoplasmic exchange
title_full_unstemmed Retinal transplantation of photoreceptors results in donor–host cytoplasmic exchange
title_sort retinal transplantation of photoreceptors results in donor–host cytoplasmic exchange
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2016-10-01
description Integration of transplanted photoreceptors into the host retina has been assumed as the underlying mechanism for vision improvement in pre-clinical studies. Here, the authors show that the majority of transplanted photoreceptors do not structurally integrate but exchange intercellular material with host cells.
url https://doi.org/10.1038/ncomms13028
work_keys_str_mv AT tiagosantosferreira retinaltransplantationofphotoreceptorsresultsindonorhostcytoplasmicexchange
AT silviallonch retinaltransplantationofphotoreceptorsresultsindonorhostcytoplasmicexchange
AT oliverborsch retinaltransplantationofphotoreceptorsresultsindonorhostcytoplasmicexchange
AT kaipostel retinaltransplantationofphotoreceptorsresultsindonorhostcytoplasmicexchange
AT jochenhaas retinaltransplantationofphotoreceptorsresultsindonorhostcytoplasmicexchange
AT mariusader retinaltransplantationofphotoreceptorsresultsindonorhostcytoplasmicexchange
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