Manufacturing of CD19 Specific CAR T-Cells and Evaluation of their Functional Activity in Vitro

Manufacturing of CD19 Specific CAR T-Cells and Evaluation of their Functional Activity in Vitro

Background. The most promising variant of adoptive immunotherapy of the B-line oncohematological diseases includes the use of cells with the chimeric antigen receptor (CAR T-cells), that showed extraordinary results in clinical studies. Aim. To manufacture CAR T-cells for the clinical use and to...

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Bibliographic Details
Main Authors: AV Petukhov, VA Markova, DV Motorin, AK Titov, NS Belozerova, PM Gershovich, AV Karabel’skii, RA Ivanov, EK Zaikova, EYu Smirnov, PA Butylin, AYu Zaritskey
Format: Article
Language:Russian
Published: Practical Medicine Publishing House 2018-01-01
Series:Kliničeskaâ onkogematologiâ
Subjects:
CAR T-cells
adoptive immunotherapy
acute lymphoblastic leukemia
non-Hodgkin’s lymphomas
lentiviral transduction
graft-versus-host reaction
сytokine release syndrome
Online Access:http://bloodjournal.ru/wp-content/uploads/2018/01/1-1.pdf

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