Transient Elastography-Based Liver Profiles in a Hospital-Based Pediatric Population in Japan.

The utility of transient elastography (FibroScan) is well studied in adults but not in children. We sought to assess the feasibility of performing FibroScans and the characteristics of FibroScan-based liver profiles in Japanese obese and non-obese children.FibroScan examinations were performed in pe...

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Main Authors: Yuki Cho, Daisuke Tokuhara, Hiroyasu Morikawa, Yuko Kuwae, Eri Hayashi, Masakazu Hirose, Takashi Hamazaki, Akemi Tanaka, Tomoyuki Kawamura, Norifumi Kawada, Haruo Shintaku
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4580651?pdf=render
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spelling doaj-d125ef4bee284a71980fedb95c9037ca2020-11-25T00:41:48ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01109e013723910.1371/journal.pone.0137239Transient Elastography-Based Liver Profiles in a Hospital-Based Pediatric Population in Japan.Yuki ChoDaisuke TokuharaHiroyasu MorikawaYuko KuwaeEri HayashiMasakazu HiroseTakashi HamazakiAkemi TanakaTomoyuki KawamuraNorifumi KawadaHaruo ShintakuThe utility of transient elastography (FibroScan) is well studied in adults but not in children. We sought to assess the feasibility of performing FibroScans and the characteristics of FibroScan-based liver profiles in Japanese obese and non-obese children.FibroScan examinations were performed in pediatric patients (age, 1-18 yr) who visited Osaka City University Hospital. Liver steatosis measured by controlled attenuation parameter (CAP), and hepatic fibrosis evaluated as the liver stiffness measurement (LSM), were compared among obese subjects (BMI percentile ≥ 90%), non-obese healthy controls, and non-obese patients with liver disease.Among 214 children examined, FibroScans were performed successfully in 201 children (93.9%; median, 11.5 yr; range, 1.3-17.6 yr; 115 male). CAP values (mean ± SD) were higher in the obese group (n = 52, 285 ± 60 dB/m) compared with the liver disease (n = 40, 202 ± 62, P < 0.001) and the control (n = 107, 179 ± 41, P < 0.001) group. LSM values were significantly higher in the obese group (5.5 ± 2.3 kPa) than in the control (3.9 ± 0.9, P < 0.001), but there were no significant differences in LSM between the liver disease group (5.4 ± 4.2) and either the obese or control group. LSM was highly correlated with CAP in the obese group (ρ = 0.511) but not in the control (ρ = 0.129) or liver disease (ρ = 0.170) groups.Childhood obesity carries a high risk of hepatic steatosis associated with increased liver stiffness. FibroScan methodology provides simultaneous determination of CAP and LSM, is feasible in children of any age, and is a non-invasive and effective screening method for hepatic steatosis and liver fibrosis in Japanese obese children.http://europepmc.org/articles/PMC4580651?pdf=render
collection DOAJ
language English
format Article
sources DOAJ
author Yuki Cho
Daisuke Tokuhara
Hiroyasu Morikawa
Yuko Kuwae
Eri Hayashi
Masakazu Hirose
Takashi Hamazaki
Akemi Tanaka
Tomoyuki Kawamura
Norifumi Kawada
Haruo Shintaku
spellingShingle Yuki Cho
Daisuke Tokuhara
Hiroyasu Morikawa
Yuko Kuwae
Eri Hayashi
Masakazu Hirose
Takashi Hamazaki
Akemi Tanaka
Tomoyuki Kawamura
Norifumi Kawada
Haruo Shintaku
Transient Elastography-Based Liver Profiles in a Hospital-Based Pediatric Population in Japan.
PLoS ONE
author_facet Yuki Cho
Daisuke Tokuhara
Hiroyasu Morikawa
Yuko Kuwae
Eri Hayashi
Masakazu Hirose
Takashi Hamazaki
Akemi Tanaka
Tomoyuki Kawamura
Norifumi Kawada
Haruo Shintaku
author_sort Yuki Cho
title Transient Elastography-Based Liver Profiles in a Hospital-Based Pediatric Population in Japan.
title_short Transient Elastography-Based Liver Profiles in a Hospital-Based Pediatric Population in Japan.
title_full Transient Elastography-Based Liver Profiles in a Hospital-Based Pediatric Population in Japan.
title_fullStr Transient Elastography-Based Liver Profiles in a Hospital-Based Pediatric Population in Japan.
title_full_unstemmed Transient Elastography-Based Liver Profiles in a Hospital-Based Pediatric Population in Japan.
title_sort transient elastography-based liver profiles in a hospital-based pediatric population in japan.
publisher Public Library of Science (PLoS)
series PLoS ONE
issn 1932-6203
publishDate 2015-01-01
description The utility of transient elastography (FibroScan) is well studied in adults but not in children. We sought to assess the feasibility of performing FibroScans and the characteristics of FibroScan-based liver profiles in Japanese obese and non-obese children.FibroScan examinations were performed in pediatric patients (age, 1-18 yr) who visited Osaka City University Hospital. Liver steatosis measured by controlled attenuation parameter (CAP), and hepatic fibrosis evaluated as the liver stiffness measurement (LSM), were compared among obese subjects (BMI percentile ≥ 90%), non-obese healthy controls, and non-obese patients with liver disease.Among 214 children examined, FibroScans were performed successfully in 201 children (93.9%; median, 11.5 yr; range, 1.3-17.6 yr; 115 male). CAP values (mean ± SD) were higher in the obese group (n = 52, 285 ± 60 dB/m) compared with the liver disease (n = 40, 202 ± 62, P < 0.001) and the control (n = 107, 179 ± 41, P < 0.001) group. LSM values were significantly higher in the obese group (5.5 ± 2.3 kPa) than in the control (3.9 ± 0.9, P < 0.001), but there were no significant differences in LSM between the liver disease group (5.4 ± 4.2) and either the obese or control group. LSM was highly correlated with CAP in the obese group (ρ = 0.511) but not in the control (ρ = 0.129) or liver disease (ρ = 0.170) groups.Childhood obesity carries a high risk of hepatic steatosis associated with increased liver stiffness. FibroScan methodology provides simultaneous determination of CAP and LSM, is feasible in children of any age, and is a non-invasive and effective screening method for hepatic steatosis and liver fibrosis in Japanese obese children.
url http://europepmc.org/articles/PMC4580651?pdf=render
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