miR‐15a‐5p, miR‐15b‐5p, and miR‐16‐5p inhibit tumor progression by directly targeting MYCN in neuroblastoma

miR‐15a‐5p, miR‐15b‐5p, and miR‐16‐5p inhibit tumor progression by directly targeting MYCN in neuroblastoma

Neuroblastoma (NB) is the most common extracranial solid malignancy in children. Despite current aggressive treatment regimens, the prognosis for high‐risk NB patients remains poor, with the survival of less than 40%. Amplification/stabilization of MYCN oncogene, in NB is associated with a high risk...

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Bibliographic Details
Main Authors: Srinivas Chava, C. Patrick Reynolds, Anup S. Pathania, Santhi Gorantla, Larisa Y. Poluektova, Don W. Coulter, Subash C. Gupta, Manoj K. Pandey, Kishore B. Challagundla
Format: Article
Language:English
Published: Wiley 2020-01-01
Series:Molecular Oncology
Subjects:
Ago2
microRNA
MYCN
neuroblastoma
patient‐derived xenografts
Online Access:https://doi.org/10.1002/1878-0261.12588

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