Conversion of 7-ketocholesterol to oxysterol metabolites by recombinant CYP27A1 and retinal pigment epithelial cells[S]

Conversion of 7-ketocholesterol to oxysterol metabolites by recombinant CYP27A1 and retinal pigment epithelial cells[S]

Of the different oxygenated cholesterol metabolites, 7-ketocholesterol (7KCh) is considered a noxious oxy­sterol implicated in the development of certain pathologies, including those found in the eye. Here we elucidated whether sterol 27-hydroxylase cytochrome P450 27A1 (CYP27A1) is involved in elim...

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Bibliographic Details
Main Authors: Gun-Young Heo, Ilya Bederman, Natalia Mast, Wei-Li Liao, Illarion V. Turko, Irina A. Pikuleva
Format: Article
Language:English
Published: Elsevier 2011-06-01
Series:Journal of Lipid Research
Subjects:
3β,27-dihydroxy-5-cholesten-7-one
3β-hydroxy-5-cholesten-7-one-26-oic acid
isotope dilution gas chromatography-mass spectrometry
age-related macular degeneration
cytochrome P450 27A1
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520313304

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http://www.sciencedirect.com/science/article/pii/S0022227520313304

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