MT-7716, a novel selective nonpeptidergic NOP receptor agonist, effectively blocks ethanol-induced increase in GABAergic transmission in the rat central amygdala

MT-7716, a novel selective nonpeptidergic NOP receptor agonist, effectively blocks ethanol-induced increase in GABAergic transmission in the rat central amygdala

The GABAergic system in the central amygdala (CeA) plays a major role in ethanol dependence and the anxiogenic-like response to ethanol withdrawal. A large body of evidence shows that Nociceptin/Orphanin FQ (N/OFQ) regulates ethanol intake and anxiety-like behavior. In the rat, ethanol significantly...

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Bibliographic Details
Main Authors: Marsida eKallupi, Christopher S. Oleata, George eLuu, Koji eTeshima, Roberto eCiccocioppo, Marisa eRoberto
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-02-01
Series:Frontiers in Integrative Neuroscience
Subjects:
Amygdala
GABA
alcohol
nociceptin
NOP receptor
and electrophysiology
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnint.2014.00018/full

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