Effects of Maternal Immune System Status on Neonate’s Immune System
Background: This study evaluated the effects of the maternal immune system stimulation or suppression during the pregnancy on the development of the neonate’s immune system.<br />Methods: A total of 20 female rats were divided into four groups. The groups were treated using Leishmania major, S...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2020-08-01
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| Series: | Iranian Journal of Neonatology |
| Subjects: | |
| Online Access: | http://ijn.mums.ac.ir/article_15708_7bef8e8292579c4eb0df48174ed7622e.pdf |
| Summary: | Background: This study evaluated the effects of the maternal immune system stimulation or suppression during the pregnancy on the development of the neonate’s immune system.<br />Methods: A total of 20 female rats were divided into four groups. The groups were treated using Leishmania major, Salmonella typhimurium, Tacrolimus, and sterilized normal saline. The animals were mated after 3-time treatments. The neonate’s humoral immune response, total body, thymus, liver, spleen weight, and histology were determined in this study.<br />Results: The spleen’s mean weight of the two-month-old samples showed a significant reduction in the Salmonella group; in addition, the Tacrolimus group had a significant reduction in liver mean weight. The Salmonella and Tacrolimus groups showed a significant reduction (P≤0.05) in the anti-sheep red blood cells antibody titer.<br />Conclusion: Stimulation or suppression of the immune responses during the pregnancy has significant effects on the neonate’s immune responses, spleen, liver, and thymus development. |
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| ISSN: | 2251-7510 2322-2158 |