Glycol chitosan-based tacrolimus-loaded nanomicelle therapy ameliorates lupus nephritis

Glycol chitosan-based tacrolimus-loaded nanomicelle therapy ameliorates lupus nephritis

Abstract Background Recently, we developed hydrophobically modified glycol chitosan (HGC) nanomicelles loaded with tacrolimus (TAC) (HGC-TAC) for the targeted renal delivery of TAC. Herein, we determined whether the administration of the HGC-TAC nanomicelles decreases kidney injury in a model of lup...

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Bibliographic Details
Main Authors: Chang Seong Kim, Ansuja Pulickal Mathew, Arathy Vasukutty, Saji Uthaman, Soo Yeon Joo, Eun Hui Bae, Seong Kwon Ma, In-Kyu Park, Soo Wan Kim
Format: Article
Language:English
Published: BMC 2021-04-01
Series:Journal of Nanobiotechnology
Subjects:
Nanomicelles
Chitosan
Adherence
Tacrolimus
Lupus nephritis
Kidney injury
Online Access:https://doi.org/10.1186/s12951-021-00857-w

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