Non-competitive resource exploitation within mosquito shapes within-host malaria infectivity and virulence

The evolution of within-host malaria virulence has been studied, but the vector’s contribution isn’t well understood. Here, Costa et al. show that non-competitive parasitic resource exploitation within-vector, in particular lipid trafficking, restricts within-host infectivity and virulence of the pa...

Full description

Bibliographic Details
Main Authors:	G. Costa, M. Gildenhard, M. Eldering, R. L. Lindquist, A. E. Hauser, R. Sauerwein, C. Goosmann, V. Brinkmann, P. Carrillo-Bustamante, E. A. Levashina
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-08-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-018-05893-z

id	doaj-d0ff37703f7c4f89aa8c57e9682c2d38
record_format	Article
spelling	doaj-d0ff37703f7c4f89aa8c57e9682c2d382021-05-11T09:59:54ZengNature Publishing GroupNature Communications2041-17232018-08-019111110.1038/s41467-018-05893-zNon-competitive resource exploitation within mosquito shapes within-host malaria infectivity and virulenceG. Costa0M. Gildenhard1M. Eldering2R. L. Lindquist3A. E. Hauser4R. Sauerwein5C. Goosmann6V. Brinkmann7P. Carrillo-Bustamante8E. A. Levashina9Vector Biology Unit, Max Planck Institute for Infection Biology (MPIIB)Vector Biology Unit, Max Planck Institute for Infection Biology (MPIIB)Vector Biology Unit, Max Planck Institute for Infection Biology (MPIIB)Immunodynamics, German Rheumatism Research Centre (DRFZ)Immunodynamics, German Rheumatism Research Centre (DRFZ)Department of Medical Microbiology, Radboud University Medical CenterMicroscopy Core Facility, Max Planck Institute for Infection Biology (MPIIB)Microscopy Core Facility, Max Planck Institute for Infection Biology (MPIIB)Vector Biology Unit, Max Planck Institute for Infection Biology (MPIIB)Vector Biology Unit, Max Planck Institute for Infection Biology (MPIIB)The evolution of within-host malaria virulence has been studied, but the vector’s contribution isn’t well understood. Here, Costa et al. show that non-competitive parasitic resource exploitation within-vector, in particular lipid trafficking, restricts within-host infectivity and virulence of the parasite.https://doi.org/10.1038/s41467-018-05893-z
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	G. Costa M. Gildenhard M. Eldering R. L. Lindquist A. E. Hauser R. Sauerwein C. Goosmann V. Brinkmann P. Carrillo-Bustamante E. A. Levashina
spellingShingle	G. Costa M. Gildenhard M. Eldering R. L. Lindquist A. E. Hauser R. Sauerwein C. Goosmann V. Brinkmann P. Carrillo-Bustamante E. A. Levashina Non-competitive resource exploitation within mosquito shapes within-host malaria infectivity and virulence Nature Communications
author_facet	G. Costa M. Gildenhard M. Eldering R. L. Lindquist A. E. Hauser R. Sauerwein C. Goosmann V. Brinkmann P. Carrillo-Bustamante E. A. Levashina
author_sort	G. Costa
title	Non-competitive resource exploitation within mosquito shapes within-host malaria infectivity and virulence
title_short	Non-competitive resource exploitation within mosquito shapes within-host malaria infectivity and virulence
title_full	Non-competitive resource exploitation within mosquito shapes within-host malaria infectivity and virulence
title_fullStr	Non-competitive resource exploitation within mosquito shapes within-host malaria infectivity and virulence
title_full_unstemmed	Non-competitive resource exploitation within mosquito shapes within-host malaria infectivity and virulence
title_sort	non-competitive resource exploitation within mosquito shapes within-host malaria infectivity and virulence
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2018-08-01
description	The evolution of within-host malaria virulence has been studied, but the vector’s contribution isn’t well understood. Here, Costa et al. show that non-competitive parasitic resource exploitation within-vector, in particular lipid trafficking, restricts within-host infectivity and virulence of the parasite.
url	https://doi.org/10.1038/s41467-018-05893-z
work_keys_str_mv	AT gcosta noncompetitiveresourceexploitationwithinmosquitoshapeswithinhostmalariainfectivityandvirulence AT mgildenhard noncompetitiveresourceexploitationwithinmosquitoshapeswithinhostmalariainfectivityandvirulence AT meldering noncompetitiveresourceexploitationwithinmosquitoshapeswithinhostmalariainfectivityandvirulence AT rllindquist noncompetitiveresourceexploitationwithinmosquitoshapeswithinhostmalariainfectivityandvirulence AT aehauser noncompetitiveresourceexploitationwithinmosquitoshapeswithinhostmalariainfectivityandvirulence AT rsauerwein noncompetitiveresourceexploitationwithinmosquitoshapeswithinhostmalariainfectivityandvirulence AT cgoosmann noncompetitiveresourceexploitationwithinmosquitoshapeswithinhostmalariainfectivityandvirulence AT vbrinkmann noncompetitiveresourceexploitationwithinmosquitoshapeswithinhostmalariainfectivityandvirulence AT pcarrillobustamante noncompetitiveresourceexploitationwithinmosquitoshapeswithinhostmalariainfectivityandvirulence AT ealevashina noncompetitiveresourceexploitationwithinmosquitoshapeswithinhostmalariainfectivityandvirulence
_version_	1721448878398504960

Non-competitive resource exploitation within mosquito shapes within-host malaria infectivity and virulence

Similar Items