Expressionchangesandrolesofmatrixmetalloproteinases

• Main Authors: zhang yu-bing, LI Wen, YAO Li-qing, ZHAO Xue-ling, WANG Bing, LI Hongkun, NING Ya, SONG En, ZHANG Xin-xin
• Format: Article
• Language: English
• Published: Elsevier 2010-06-01
• Series: Chinese Journal of Traumatology
• Online Access: http://www.cjtrauma.com/apps/ojs/index.php/cjt/article/view/12

Traumatic deep vein thrombosis (TDVT) refers to deep vein thrombosis resulting from trauma or operation. It is common and can bring about multiple complications such as phlegmasia cerulean dolens that requires limb amputation and life-threatening pulmonary thromboembolism. Studies at cellular andmolecular levels reveal that local cells change after trauma and generate corresponding expression products that further change cell function and transmit messages around according to increased, decreased, activated or unactivated gene expressions. Previous studies have shown that TDVT is a complex disease with multiple factors, genes and systems involved in.1,2Matrix metallo-proteinases (MMPs), which result in excessive degradation of the endothelial basement membrane, are one of themain factors that affect thrombosis and thrombus resolution and the mechanisms have become a hotspot in recent years.