Streptococcal Lancefield polysaccharides are critical cell wall determinants for human Group IIA secreted phospholipase A2 to exert its bactericidal effects.

Streptococcal Lancefield polysaccharides are critical cell wall determinants for human Group IIA secreted phospholipase A2 to exert its bactericidal effects.

Human Group IIA secreted phospholipase A2 (hGIIA) is an acute phase protein with bactericidal activity against Gram-positive bacteria. Infection models in hGIIA transgenic mice have suggested the importance of hGIIA as an innate defense mechanism against the human pathogens Group A Streptococcus (GA...

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Bibliographic Details
Main Authors: Vincent P van Hensbergen, Elin Movert, Vincent de Maat, Christian Lüchtenborg, Yoann Le Breton, Gérard Lambeau, Christine Payré, Anna Henningham, Victor Nizet, Jos A G van Strijp, Britta Brügger, Fredric Carlsson, Kevin S McIver, Nina M van Sorge
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-10-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1007348

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