Mathematical modelling of cancer invasion: The role of membrane-bound matrix metalloproteinases

One of the hallmarks of cancer growth and metastatic spread is the process of local invasion of the surrounding tissue. Cancer cells achieve protease- dependent invasion by the secretion of enzymes involved in proteolysis. These overly-expressed proteolytic enzymes then proceed to degrade the host t...

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Bibliographic Details
Main Authors: Mark AJ Chaplain, Niall eDeakin
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-04-01
Series:Frontiers in Oncology
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2013.00070/full