N-Acetyl-Seryl-Aspartyl-Lysyl-Proline Mitigates Experimental Colitis Through Inhibition of Intestinal Mucosal Inflammatory Responses via MEK-ERK Signaling

N-Acetyl-Seryl-Aspartyl-Lysyl-Proline Mitigates Experimental Colitis Through Inhibition of Intestinal Mucosal Inflammatory Responses via MEK-ERK Signaling

N-acetyl-seryl-aspartyl-lysyl-proline (AcSDKP) is an endogenous immunomodulatory peptide that is generated from thymosin β4 (Tβ4) through stepwise hydrolysis, involving meprin-α and prolyl endopeptidase (PREP). It is well acknowledged that AcSDKP exerts beneficial effects on multiple cardiovascular...

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Bibliographic Details
Main Authors: Yingying Shi, Mingxia Zhou, Junkai Yan, Zizhen Gong, Jin Wu, Yuanwen Chen, Yingwei Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Pharmacology
Subjects:
N-acetyl-seryl-aspartyl-lysyl-proline
prolyl endopeptidase
colitis
intestinal epithelial cell
MEK-ERK signaling
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00593/full

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https://www.frontiersin.org/article/10.3389/fphar.2020.00593/full

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