A nanounit strategy reverses immune suppression of exosomal PD-L1 and is associated with enhanced ferroptosis
PD-L1 is frequently expressed on the surface of cancer cells and can be excreted from cancer cells in exosomes. Here, the authors generate a nanotherapy that combines an inhibitor of exosome production and an inducer of ferroptosis, enhancing the response to immune checkpoint blockade therapy.
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2021-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-25990-w |