A nanounit strategy reverses immune suppression of exosomal PD-L1 and is associated with enhanced ferroptosis

PD-L1 is frequently expressed on the surface of cancer cells and can be excreted from cancer cells in exosomes. Here, the authors generate a nanotherapy that combines an inhibitor of exosome production and an inducer of ferroptosis, enhancing the response to immune checkpoint blockade therapy.

Bibliographic Details
Main Authors:	Guohao Wang, Lisi Xie, Bei Li, Wei Sang, Jie Yan, Jie Li, Hao Tian, Wenxi Li, Zhan Zhang, Ye Tian, Yunlu Dai
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-09-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-021-25990-w

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spelling	doaj-d0e25276be7f4139860cffdfc046439d2021-10-03T11:50:13ZengNature Publishing GroupNature Communications2041-17232021-09-0112111210.1038/s41467-021-25990-wA nanounit strategy reverses immune suppression of exosomal PD-L1 and is associated with enhanced ferroptosisGuohao Wang0Lisi Xie1Bei Li2Wei Sang3Jie Yan4Jie Li5Hao Tian6Wenxi Li7Zhan Zhang8Ye Tian9Yunlu Dai10Cancer Centre, Faculty of Health Sciences, University of MacauCancer Centre, Faculty of Health Sciences, University of MacauCancer Centre, Faculty of Health Sciences, University of MacauCancer Centre, Faculty of Health Sciences, University of MacauCancer Centre, Faculty of Health Sciences, University of MacauCancer Centre, Faculty of Health Sciences, University of MacauCancer Centre, Faculty of Health Sciences, University of MacauCancer Centre, Faculty of Health Sciences, University of MacauCancer Centre, Faculty of Health Sciences, University of MacauCancer Centre, Faculty of Health Sciences, University of MacauCancer Centre, Faculty of Health Sciences, University of MacauPD-L1 is frequently expressed on the surface of cancer cells and can be excreted from cancer cells in exosomes. Here, the authors generate a nanotherapy that combines an inhibitor of exosome production and an inducer of ferroptosis, enhancing the response to immune checkpoint blockade therapy.https://doi.org/10.1038/s41467-021-25990-w
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Guohao Wang Lisi Xie Bei Li Wei Sang Jie Yan Jie Li Hao Tian Wenxi Li Zhan Zhang Ye Tian Yunlu Dai
spellingShingle	Guohao Wang Lisi Xie Bei Li Wei Sang Jie Yan Jie Li Hao Tian Wenxi Li Zhan Zhang Ye Tian Yunlu Dai A nanounit strategy reverses immune suppression of exosomal PD-L1 and is associated with enhanced ferroptosis Nature Communications
author_facet	Guohao Wang Lisi Xie Bei Li Wei Sang Jie Yan Jie Li Hao Tian Wenxi Li Zhan Zhang Ye Tian Yunlu Dai
author_sort	Guohao Wang
title	A nanounit strategy reverses immune suppression of exosomal PD-L1 and is associated with enhanced ferroptosis
title_short	A nanounit strategy reverses immune suppression of exosomal PD-L1 and is associated with enhanced ferroptosis
title_full	A nanounit strategy reverses immune suppression of exosomal PD-L1 and is associated with enhanced ferroptosis
title_fullStr	A nanounit strategy reverses immune suppression of exosomal PD-L1 and is associated with enhanced ferroptosis
title_full_unstemmed	A nanounit strategy reverses immune suppression of exosomal PD-L1 and is associated with enhanced ferroptosis
title_sort	nanounit strategy reverses immune suppression of exosomal pd-l1 and is associated with enhanced ferroptosis
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2021-09-01
description	PD-L1 is frequently expressed on the surface of cancer cells and can be excreted from cancer cells in exosomes. Here, the authors generate a nanotherapy that combines an inhibitor of exosome production and an inducer of ferroptosis, enhancing the response to immune checkpoint blockade therapy.
url	https://doi.org/10.1038/s41467-021-25990-w
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A nanounit strategy reverses immune suppression of exosomal PD-L1 and is associated with enhanced ferroptosis

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