A nanounit strategy reverses immune suppression of exosomal PD-L1 and is associated with enhanced ferroptosis
PD-L1 is frequently expressed on the surface of cancer cells and can be excreted from cancer cells in exosomes. Here, the authors generate a nanotherapy that combines an inhibitor of exosome production and an inducer of ferroptosis, enhancing the response to immune checkpoint blockade therapy.
Bibliographic Details
| Main Authors: |
Guohao Wang,
Lisi Xie,
Bei Li,
Wei Sang,
Jie Yan,
Jie Li,
Hao Tian,
Wenxi Li,
Zhan Zhang,
Ye Tian,
Yunlu Dai |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2021-09-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-021-25990-w
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