N6-Methyladenosine RNA Modification in Inflammation: Roles, Mechanisms, and Applications

N6-Methyladenosine RNA Modification in Inflammation: Roles, Mechanisms, and Applications

N6-methyladenosine (m6A) is the most prevalent internal mRNA modification. m6A can be installed by the methyltransferase complex and removed by demethylases, which are involved in regulating post-transcriptional expression of target genes. RNA methylation is linked to various inflammatory states, in...

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Main Authors: Jiahui Luo, Tao Xu, Kai Sun
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
N6-methyladenosine
RNA modification
epigenetics
inflammation
inflammatory disease
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.670711/full
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spelling doaj-d0ded3a9703045a481dad0acfba0423e2021-06-04T08:14:55ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2021-06-01910.3389/fcell.2021.670711670711N6-Methyladenosine RNA Modification in Inflammation: Roles, Mechanisms, and ApplicationsJiahui Luo0Tao Xu1Kai Sun2The Center for Biomedical Research, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Rehabilitation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaN6-methyladenosine (m6A) is the most prevalent internal mRNA modification. m6A can be installed by the methyltransferase complex and removed by demethylases, which are involved in regulating post-transcriptional expression of target genes. RNA methylation is linked to various inflammatory states, including autoimmunity, infection, metabolic disease, cancer, neurodegenerative diseases, heart diseases, and bone diseases. However, systematic knowledge of the relationship between m6A modification and inflammation in human diseases remains unclear. In this review, we will discuss the association between m6A modification and inflammatory response in diseases, especially the role, mechanisms, and potential clinical application of m6A as a biomarker and therapeutic target for inflammatory diseases.https://www.frontiersin.org/articles/10.3389/fcell.2021.670711/fullN6-methyladenosineRNA modificationepigeneticsinflammationinflammatory disease
collection DOAJ
language English
format Article
sources DOAJ
author Jiahui Luo
Tao Xu
Kai Sun
spellingShingle Jiahui Luo
Tao Xu
Kai Sun
N6-Methyladenosine RNA Modification in Inflammation: Roles, Mechanisms, and Applications
Frontiers in Cell and Developmental Biology
N6-methyladenosine
RNA modification
epigenetics
inflammation
inflammatory disease
author_facet Jiahui Luo
Tao Xu
Kai Sun
author_sort Jiahui Luo
title N6-Methyladenosine RNA Modification in Inflammation: Roles, Mechanisms, and Applications
title_short N6-Methyladenosine RNA Modification in Inflammation: Roles, Mechanisms, and Applications
title_full N6-Methyladenosine RNA Modification in Inflammation: Roles, Mechanisms, and Applications
title_fullStr N6-Methyladenosine RNA Modification in Inflammation: Roles, Mechanisms, and Applications
title_full_unstemmed N6-Methyladenosine RNA Modification in Inflammation: Roles, Mechanisms, and Applications
title_sort n6-methyladenosine rna modification in inflammation: roles, mechanisms, and applications
publisher Frontiers Media S.A.
series Frontiers in Cell and Developmental Biology
issn 2296-634X
publishDate 2021-06-01
description N6-methyladenosine (m6A) is the most prevalent internal mRNA modification. m6A can be installed by the methyltransferase complex and removed by demethylases, which are involved in regulating post-transcriptional expression of target genes. RNA methylation is linked to various inflammatory states, including autoimmunity, infection, metabolic disease, cancer, neurodegenerative diseases, heart diseases, and bone diseases. However, systematic knowledge of the relationship between m6A modification and inflammation in human diseases remains unclear. In this review, we will discuss the association between m6A modification and inflammatory response in diseases, especially the role, mechanisms, and potential clinical application of m6A as a biomarker and therapeutic target for inflammatory diseases.
topic N6-methyladenosine
RNA modification
epigenetics
inflammation
inflammatory disease
url https://www.frontiersin.org/articles/10.3389/fcell.2021.670711/full
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AT taoxu n6methyladenosinernamodificationininflammationrolesmechanismsandapplications
AT kaisun n6methyladenosinernamodificationininflammationrolesmechanismsandapplications
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