Scavenger receptor-A is a biomarker and effector of rheumatoid arthritis: A large-scale multicenter study
Scavenger receptor-A (SR-A) is mostly expressed by myeloid cells and has been attributed a variety of biological functions. Here the authors assess SR-A as a biomarker for diagnosis of rheumatoid arthritis (RA) using large-scale training and validation cohorts and show that modulating SR-A levels ca...
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2020-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-15700-3 |
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Article |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Fanlei Hu Xiang Jiang Chunqing Guo Yingni Li Shixian Chen Wei Zhang Yan Du Ping Wang Xi Zheng Xiangyu Fang Xin Li Jing Song Yang Xie Fei Huang Jimeng Xue Mingxin Bai Yuan Jia Xu Liu Limin Ren Xiaoying Zhang Jianping Guo Hudan Pan Yin Su Huanfa Yi Hua Ye Daming Zuo Juan Li Huaxiang Wu Yongfu Wang Ru Li Liang Liu Xiang-Yang Wang Zhanguo Li |
| spellingShingle |
Fanlei Hu Xiang Jiang Chunqing Guo Yingni Li Shixian Chen Wei Zhang Yan Du Ping Wang Xi Zheng Xiangyu Fang Xin Li Jing Song Yang Xie Fei Huang Jimeng Xue Mingxin Bai Yuan Jia Xu Liu Limin Ren Xiaoying Zhang Jianping Guo Hudan Pan Yin Su Huanfa Yi Hua Ye Daming Zuo Juan Li Huaxiang Wu Yongfu Wang Ru Li Liang Liu Xiang-Yang Wang Zhanguo Li Scavenger receptor-A is a biomarker and effector of rheumatoid arthritis: A large-scale multicenter study Nature Communications |
| author_facet |
Fanlei Hu Xiang Jiang Chunqing Guo Yingni Li Shixian Chen Wei Zhang Yan Du Ping Wang Xi Zheng Xiangyu Fang Xin Li Jing Song Yang Xie Fei Huang Jimeng Xue Mingxin Bai Yuan Jia Xu Liu Limin Ren Xiaoying Zhang Jianping Guo Hudan Pan Yin Su Huanfa Yi Hua Ye Daming Zuo Juan Li Huaxiang Wu Yongfu Wang Ru Li Liang Liu Xiang-Yang Wang Zhanguo Li |
| author_sort |
Fanlei Hu |
| title |
Scavenger receptor-A is a biomarker and effector of rheumatoid arthritis: A large-scale multicenter study |
| title_short |
Scavenger receptor-A is a biomarker and effector of rheumatoid arthritis: A large-scale multicenter study |
| title_full |
Scavenger receptor-A is a biomarker and effector of rheumatoid arthritis: A large-scale multicenter study |
| title_fullStr |
Scavenger receptor-A is a biomarker and effector of rheumatoid arthritis: A large-scale multicenter study |
| title_full_unstemmed |
Scavenger receptor-A is a biomarker and effector of rheumatoid arthritis: A large-scale multicenter study |
| title_sort |
scavenger receptor-a is a biomarker and effector of rheumatoid arthritis: a large-scale multicenter study |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2020-04-01 |
| description |
Scavenger receptor-A (SR-A) is mostly expressed by myeloid cells and has been attributed a variety of biological functions. Here the authors assess SR-A as a biomarker for diagnosis of rheumatoid arthritis (RA) using large-scale training and validation cohorts and show that modulating SR-A levels can alter progression of collagen-induced arthritis in mice. |
| url |
https://doi.org/10.1038/s41467-020-15700-3 |
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1721450828504498176 |
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doaj-d0dc96c37f214a199f16725f1f4d38ba2021-05-11T08:24:13ZengNature Publishing GroupNature Communications2041-17232020-04-0111111410.1038/s41467-020-15700-3Scavenger receptor-A is a biomarker and effector of rheumatoid arthritis: A large-scale multicenter studyFanlei Hu0Xiang Jiang1Chunqing Guo2Yingni Li3Shixian Chen4Wei Zhang5Yan Du6Ping Wang7Xi Zheng8Xiangyu Fang9Xin Li10Jing Song11Yang Xie12Fei Huang13Jimeng Xue14Mingxin Bai15Yuan Jia16Xu Liu17Limin Ren18Xiaoying Zhang19Jianping Guo20Hudan Pan21Yin Su22Huanfa Yi23Hua Ye24Daming Zuo25Juan Li26Huaxiang Wu27Yongfu Wang28Ru Li29Liang Liu30Xiang-Yang Wang31Zhanguo Li32Department of Rheumatology and Immunology, Peking University People’s Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135)Department of Rheumatology and Immunology, Peking University People’s Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135)Department of Human & Molecular Genetics, Virginia Commonwealth University, School of MedicineDepartment of Rheumatology and Immunology, Peking University People’s Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135)Department of Traditional Chinese Internal Medicine, School of Traditional Chinese Medicine, Southern Medical UniversityDepartment of Rheumatology and Immunology, First Hospital Affiliated to Baotou Medical College & Inner Mongolia Key Laboratory of AutoimmunityDepartment of Rheumatology, the Second Affiliated Hospital, Zhejiang University School of MedicineDepartment of Rheumatology and Immunology, Peking University People’s Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135)Department of Rheumatology and Immunology, Peking University People’s Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135)Department of Rheumatology and Immunology, Peking University People’s Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135)Department of Rheumatology and Immunology, Peking University People’s Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135)Department of Rheumatology and Immunology, Peking University People’s Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135)Department of Rheumatology and Immunology, Peking University People’s Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135)Department of Rheumatology and Immunology, Peking University People’s Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135)Department of Rheumatology and Immunology, Peking University People’s Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135)Department of Rheumatology and Immunology, Peking University People’s Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135)Department of Rheumatology and Immunology, Peking University People’s Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135)Department of Rheumatology and Immunology, Peking University People’s Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135)Department of Rheumatology and Immunology, Peking University People’s Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135)Department of Rheumatology and Immunology, Peking University People’s Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135)Department of Rheumatology and Immunology, Peking University People’s Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135)State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and TechnologyDepartment of Rheumatology and Immunology, Peking University People’s Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135)Department of Human & Molecular Genetics, Virginia Commonwealth University, School of MedicineDepartment of Rheumatology and Immunology, Peking University People’s Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135)Department of Human & Molecular Genetics, Virginia Commonwealth University, School of MedicineDepartment of Traditional Chinese Internal Medicine, School of Traditional Chinese Medicine, Southern Medical UniversityDepartment of Rheumatology, the Second Affiliated Hospital, Zhejiang University School of MedicineDepartment of Rheumatology and Immunology, First Hospital Affiliated to Baotou Medical College & Inner Mongolia Key Laboratory of AutoimmunityDepartment of Rheumatology and Immunology, Peking University People’s Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135)State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and TechnologyDepartment of Human & Molecular Genetics, Virginia Commonwealth University, School of MedicineDepartment of Rheumatology and Immunology, Peking University People’s Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135)Scavenger receptor-A (SR-A) is mostly expressed by myeloid cells and has been attributed a variety of biological functions. Here the authors assess SR-A as a biomarker for diagnosis of rheumatoid arthritis (RA) using large-scale training and validation cohorts and show that modulating SR-A levels can alter progression of collagen-induced arthritis in mice.https://doi.org/10.1038/s41467-020-15700-3 |