HIV-associated adipose redistribution syndrome (HARS): etiology and pathophysiological mechanisms

HIV-associated adipose redistribution syndrome (HARS): etiology and pathophysiological mechanisms

<p>Abstract</p> <p>Human immunodeficiency virus (HIV)-associated adipose redistribution syndrome (HARS) is a fat accumulation disorder characterized by increases in visceral adipose tissue. Patients with HARS may also present with excess truncal fat and accumulation of dorsocervica...

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Main Authors: Sekhar Rajagopal, Balasubramanyam Ashok, Lichtenstein Kenneth, Freedland Eric
Format: Article
Language:English
Published: BMC 2007-06-01
Series:AIDS Research and Therapy
Online Access:http://www.aidsrestherapy.com/content/4/1/14
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spelling doaj-d0cb35e636c1495d8734487b0cb87a972020-11-25T00:47:08ZengBMCAIDS Research and Therapy1742-64052007-06-01411410.1186/1742-6405-4-14HIV-associated adipose redistribution syndrome (HARS): etiology and pathophysiological mechanismsSekhar RajagopalBalasubramanyam AshokLichtenstein KennethFreedland Eric<p>Abstract</p> <p>Human immunodeficiency virus (HIV)-associated adipose redistribution syndrome (HARS) is a fat accumulation disorder characterized by increases in visceral adipose tissue. Patients with HARS may also present with excess truncal fat and accumulation of dorsocervical fat ("buffalo hump"). The pathophysiology of HARS appears multifactorial and is not fully understood at present. Key pathophysiological influences include adipocyte dysfunction and an excessive free fatty acid release by adipocyte lipolysis. The contributory roles of free fatty acids, cytokines, hormones including cortisol, insulin and the growth hormone-adipocyte axis are significant. Other potential humoral, paracrine, endocrine, and neural influences are also discussed.</p> http://www.aidsrestherapy.com/content/4/1/14
collection DOAJ
language English
format Article
sources DOAJ
author Sekhar Rajagopal
Balasubramanyam Ashok
Lichtenstein Kenneth
Freedland Eric
spellingShingle Sekhar Rajagopal
Balasubramanyam Ashok
Lichtenstein Kenneth
Freedland Eric
HIV-associated adipose redistribution syndrome (HARS): etiology and pathophysiological mechanisms
AIDS Research and Therapy
author_facet Sekhar Rajagopal
Balasubramanyam Ashok
Lichtenstein Kenneth
Freedland Eric
author_sort Sekhar Rajagopal
title HIV-associated adipose redistribution syndrome (HARS): etiology and pathophysiological mechanisms
title_short HIV-associated adipose redistribution syndrome (HARS): etiology and pathophysiological mechanisms
title_full HIV-associated adipose redistribution syndrome (HARS): etiology and pathophysiological mechanisms
title_fullStr HIV-associated adipose redistribution syndrome (HARS): etiology and pathophysiological mechanisms
title_full_unstemmed HIV-associated adipose redistribution syndrome (HARS): etiology and pathophysiological mechanisms
title_sort hiv-associated adipose redistribution syndrome (hars): etiology and pathophysiological mechanisms
publisher BMC
series AIDS Research and Therapy
issn 1742-6405
publishDate 2007-06-01
description <p>Abstract</p> <p>Human immunodeficiency virus (HIV)-associated adipose redistribution syndrome (HARS) is a fat accumulation disorder characterized by increases in visceral adipose tissue. Patients with HARS may also present with excess truncal fat and accumulation of dorsocervical fat ("buffalo hump"). The pathophysiology of HARS appears multifactorial and is not fully understood at present. Key pathophysiological influences include adipocyte dysfunction and an excessive free fatty acid release by adipocyte lipolysis. The contributory roles of free fatty acids, cytokines, hormones including cortisol, insulin and the growth hormone-adipocyte axis are significant. Other potential humoral, paracrine, endocrine, and neural influences are also discussed.</p>
url http://www.aidsrestherapy.com/content/4/1/14
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AT lichtensteinkenneth hivassociatedadiposeredistributionsyndromeharsetiologyandpathophysiologicalmechanisms
AT freedlanderic hivassociatedadiposeredistributionsyndromeharsetiologyandpathophysiologicalmechanisms
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