Macrophage spatial heterogeneity in gastric cancer defined by multiplex immunohistochemistry

Macrophage spatial heterogeneity in gastric cancer defined by multiplex immunohistochemistry

Tumor associated macrophages are functionally and phenotypically heterogeneous. Here the authors describe the spatial distribution of distinct macrophage populations within regions of gastric cancer and probe their associations with clinical outcomes, gene signatures and PDL1 expression.

Bibliographic Details
Main Authors: Yu-Kuan Huang, Minyu Wang, Yu Sun, Natasha Di Costanzo, Catherine Mitchell, Adrian Achuthan, John A. Hamilton, Rita A. Busuttil, Alex Boussioutas
Format: Article
Language:English
Published: Nature Publishing Group 2019-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-11788-4
Description
Summary:Tumor associated macrophages are functionally and phenotypically heterogeneous. Here the authors describe the spatial distribution of distinct macrophage populations within regions of gastric cancer and probe their associations with clinical outcomes, gene signatures and PDL1 expression.
ISSN:2041-1723

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