Proteinase-Activated Receptor 2 May Drive Cancer Progression by Facilitating TGF-β Signaling

Proteinase-Activated Receptor 2 May Drive Cancer Progression by Facilitating TGF-β Signaling

The G protein-coupled receptor proteinase-activated receptor 2 (PAR2) has been implicated in various aspects of cellular physiology including inflammation, obesity and cancer. In cancer, it usually acts as a driver of cancer progression in various tumor types by promoting invasion and metastasis in...

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Bibliographic Details
Main Authors:	Hendrik Ungefroren, David Witte, Bernhard H. Rauch, Utz Settmacher, Hendrik Lehnert, Frank Gieseler, Roland Kaufmann
Format:	Article
Language:	English
Published:	MDPI AG 2017-11-01
Series:	International Journal of Molecular Sciences
Subjects:	pancreatic carcinoma signaling TGF-β ALK5 PAR2 serine proteinases
Online Access:	https://www.mdpi.com/1422-0067/18/11/2494

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