IL-4/IL-13 Stimulated Macrophages Enhance Breast Cancer Invasion Via Rho-GTPase Regulation of Synergistic VEGF/CCL-18 Signaling

IL-4/IL-13 Stimulated Macrophages Enhance Breast Cancer Invasion Via Rho-GTPase Regulation of Synergistic VEGF/CCL-18 Signaling

Tumor associated macrophages (TAMs) are increasingly recognized as major contributors to the metastatic progression of breast cancer and enriched levels of TAMs often correlate with poor prognosis. Despite our current advances it remains unclear which subset of M2-like macrophages have the highest c...

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Bibliographic Details
Main Authors: Andrew C. Little, Pragathi Pathanjeli, Zhifen Wu, Liwei Bao, Laura E. Goo, Joel A. Yates, C. Ryan Oliver, Matthew B. Soellner, Sofia D. Merajver
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Oncology
Subjects:
Rho (Rho GTPase)
metastasis
invasion
breast cancer
migration
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.00456/full

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