One-pot synthesis of cyanohydrin derivatives from alkyl bromides via incorporation of two one-carbon components by consecutive radical/ionic reactions

One-pot synthesis of cyanohydrin derivatives from alkyl bromides via incorporation of two one-carbon components by consecutive radical/ionic reactions

The consecutive radical/ionic reaction consisting of radical formylation of alkyl bromides and nucleophilic addition of a cyanide ion was investigated, which gave moderate to good yields of cyanohydrin derivatives in one-pot.

Bibliographic Details
Main Authors: Shuhei Sumino, Akira Fusano, Hiroyuki Okai, Takahide Fukuyama, Ilhyong Ryu
Format: Article
Language:English
Published: Beilstein-Institut 2014-01-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
alkyl bromide
carbon monoxide
cyanohydrin
ethyl cyanoformate
multicomponent
radical reaction
Online Access:https://doi.org/10.3762/bjoc.10.12
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spelling doaj-d0a973546ea0491c8d31df26c288828c2021-02-02T01:57:45ZengBeilstein-InstitutBeilstein Journal of Organic Chemistry1860-53972014-01-0110115015410.3762/bjoc.10.121860-5397-10-12One-pot synthesis of cyanohydrin derivatives from alkyl bromides via incorporation of two one-carbon components by consecutive radical/ionic reactionsShuhei Sumino0Akira Fusano1Hiroyuki Okai2Takahide Fukuyama3Ilhyong Ryu4Department of Chemistry, Graduate School of Science, Osaka Prefecture University, Sakai, Osaka 599-8531, JapanDepartment of Chemistry, Graduate School of Science, Osaka Prefecture University, Sakai, Osaka 599-8531, JapanDepartment of Chemistry, Graduate School of Science, Osaka Prefecture University, Sakai, Osaka 599-8531, JapanDepartment of Chemistry, Graduate School of Science, Osaka Prefecture University, Sakai, Osaka 599-8531, JapanDepartment of Chemistry, Graduate School of Science, Osaka Prefecture University, Sakai, Osaka 599-8531, JapanThe consecutive radical/ionic reaction consisting of radical formylation of alkyl bromides and nucleophilic addition of a cyanide ion was investigated, which gave moderate to good yields of cyanohydrin derivatives in one-pot.https://doi.org/10.3762/bjoc.10.12alkyl bromidecarbon monoxidecyanohydrinethyl cyanoformatemulticomponentradical reaction
collection DOAJ
language English
format Article
sources DOAJ
author Shuhei Sumino
Akira Fusano
Hiroyuki Okai
Takahide Fukuyama
Ilhyong Ryu
spellingShingle Shuhei Sumino
Akira Fusano
Hiroyuki Okai
Takahide Fukuyama
Ilhyong Ryu
One-pot synthesis of cyanohydrin derivatives from alkyl bromides via incorporation of two one-carbon components by consecutive radical/ionic reactions
Beilstein Journal of Organic Chemistry
alkyl bromide
carbon monoxide
cyanohydrin
ethyl cyanoformate
multicomponent
radical reaction
author_facet Shuhei Sumino
Akira Fusano
Hiroyuki Okai
Takahide Fukuyama
Ilhyong Ryu
author_sort Shuhei Sumino
title One-pot synthesis of cyanohydrin derivatives from alkyl bromides via incorporation of two one-carbon components by consecutive radical/ionic reactions
title_short One-pot synthesis of cyanohydrin derivatives from alkyl bromides via incorporation of two one-carbon components by consecutive radical/ionic reactions
title_full One-pot synthesis of cyanohydrin derivatives from alkyl bromides via incorporation of two one-carbon components by consecutive radical/ionic reactions
title_fullStr One-pot synthesis of cyanohydrin derivatives from alkyl bromides via incorporation of two one-carbon components by consecutive radical/ionic reactions
title_full_unstemmed One-pot synthesis of cyanohydrin derivatives from alkyl bromides via incorporation of two one-carbon components by consecutive radical/ionic reactions
title_sort one-pot synthesis of cyanohydrin derivatives from alkyl bromides via incorporation of two one-carbon components by consecutive radical/ionic reactions
publisher Beilstein-Institut
series Beilstein Journal of Organic Chemistry
issn 1860-5397
publishDate 2014-01-01
description The consecutive radical/ionic reaction consisting of radical formylation of alkyl bromides and nucleophilic addition of a cyanide ion was investigated, which gave moderate to good yields of cyanohydrin derivatives in one-pot.
topic alkyl bromide
carbon monoxide
cyanohydrin
ethyl cyanoformate
multicomponent
radical reaction
url https://doi.org/10.3762/bjoc.10.12
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AT takahidefukuyama onepotsynthesisofcyanohydrinderivativesfromalkylbromidesviaincorporationoftwoonecarboncomponentsbyconsecutiveradicalionicreactions
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