Acetylcholinesterase induces the expression of the β-amyloid precursor protein in glia and activates glial cells in culture

Acetylcholinesterase induces the expression of the β-amyloid precursor protein in glia and activates glial cells in culture

Acetylcholinesterase (AChE) activities in CNS physiopathology are increasingly diverse and range from neuritogenesis, through synaptogenesis, to enhancement of amyloid fiber assembly. In Alzheimer's disease, senile plaques and neurodegeneration specially affect regions enriched for cholinergic...

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Bibliographic Details
Main Authors: Rommy von Bernhardi, Gigliola Ramírez, Giancarlo V De Ferrari, Nibaldo C Inestrosa
Format: Article
Language:English
Published: Elsevier 2003-12-01
Series:Neurobiology of Disease
Subjects:
Acetylcholinesterase
AChE inhibitors
β-APP
Alzheimer's disease
iNOS
Glia
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996103001591

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