Humanization of the Prostate Microenvironment Reduces Homing of PC3 Prostate Cancer Cells to Human Tissue-Engineered Bone

Humanization of the Prostate Microenvironment Reduces Homing of PC3 Prostate Cancer Cells to Human Tissue-Engineered Bone

The primary tumor microenvironment is inherently important in prostate cancer (PCa) initiation, growth and metastasis. However, most current PCa animal models are based on the injection of cancer cells into the blood circulation and bypass the first steps of the metastatic cascade, hence failing to...

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Bibliographic Details
Main Authors: Jacqui A. McGovern, Abbas Shafiee, Ferdinand Wagner, Christoph A. Lahr, Marietta Landgraf, Christoph Meinert, Elizabeth D. Williams, Pamela J. Russell, Judith A. Clements, Daniela Loessner, Boris M. Holzapfel, Gail P. Risbridger, Dietmar W. Hutmacher
Format: Article
Language:English
Published: MDPI AG 2018-11-01
Series:Cancers
Subjects:
prostate cancer
bone metastasis
tissue engineering
humanized bone
orthotopic model
cancer-associated fibroblasts
tumor microenvironment
Online Access:https://www.mdpi.com/2072-6694/10/11/438

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