Requirement of the transcription factor YB-1 for maintaining the stemness of cancer stem cells and reverting differentiated cancer cells into cancer stem cells

Requirement of the transcription factor YB-1 for maintaining the stemness of cancer stem cells and reverting differentiated cancer cells into cancer stem cells

Abstract Background Cancer stem cells always express high levels of stemness-associated transcription factors to maintain their features. However, the regulatory mechanism of the stemness of cancer stem cells mediated by transcription factors has not been extensively explored. Methods The YB-1 gene...

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Bibliographic Details
Main Authors: Fan Yang, Pei Cui, Yu Lu, Xiaobo Zhang
Format: Article
Language:English
Published: BMC 2019-08-01
Series:Stem Cell Research & Therapy
Subjects:
Cancer stem cell
Transcription factor
YB-1
Stemness
Online Access:http://link.springer.com/article/10.1186/s13287-019-1360-4

Internet

http://link.springer.com/article/10.1186/s13287-019-1360-4

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