Dichloroacetate and PX-478 exhibit strong synergistic effects in a various number of cancer cell lines

Dichloroacetate and PX-478 exhibit strong synergistic effects in a various number of cancer cell lines

Abstract Background One key approach for anticancer therapy is drug combination. Drug combinations can help reduce doses and thereby decrease side effects. Furthermore, the likelihood of drug resistance is reduced. Distinct alterations in tumor metabolism have been described in past decades, but met...

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Bibliographic Details
Main Authors: Jonas Parczyk, Jérôme Ruhnau, Carsten Pelz, Max Schilling, Hao Wu, Nicole Nadine Piaskowski, Britta Eickholt, Hartmut Kühn, Kerstin Danker, Andreas Klein
Format: Article
Language:English
Published: BMC 2021-04-01
Series:BMC Cancer
Subjects:
PX-478
HIF-1α inhibition
Dichloroacetate
Synergism
Cancer therapy
Drug combination
Online Access:https://doi.org/10.1186/s12885-021-08186-9

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