Correlation between serum ANXA7, miR-211 levels and RAGE gene polymorphisms and postoperative recurrence of ESD after smokinginduced gastric cancer

• Main Authors: Min Zhang, Xiao-Qing Zhou, Bao-Hua Li
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2019-07-01
• Series: Journal of Hainan Medical University
• Subjects: gastric cancer; smoking; annexin-vii; mir-211; receptor for advanced glycation end products; gene polymorphism; recurrence
• Online Access: http://www.hnykdxxb.com/PDF/201914/07.pdf

Objective: To investigate the correlation between serum ANXA7, miR-211 levels and RAGE gene polymorphisms and postoperative recurrence of ESD after smoking-induced gastric cancer. Methods: A total of 400 patients with gastric cancer who underwent ESD were randomly divided into recurrent group and non-recurred group according to whether they were relapsed. According to whether smoking was classified as smoking recurrence and smoking no recurrence group. Serum ANXA7, miR-211 levels and RAGE gene polymorphisms were compared between groups. Results: The smoking rate and serum ANXA7 and miR-211 levels in the relapse group were significantly higher than those in the non-recurrent group (P<0.05). Moreover, the polymorphisms of RAGE gene rs2070600 and rs184003 may be associated with the recurrence of gastric cancer (P<0.05). The levels of serum ANXA7 and miR-211 in the smoke relapse group were significantly higher than those in the non-recurrence group (P<0.05). Moreover, the polymorphisms of RAGE gene rs2070600 and rs184003 may be associated with recurrence of ESD after smoking-induced gastric cancer (P<0.05). The polymorphisms of serum ANXA7, miR-211 and RAGE genes may be associated with recurrence of ESD after smoking-induced gastric cancer (P<0.05). Conclusion: Smoking may be one of the factors that induce recurrence of gastric cancer after ESD, and smoking may cause elevation of serum ANXA7, miR-211 and mutation of RAGE gene, which may induce recurrence of gastric cancer after ESD.