Carotid intima-media thickness among normoglycemia and normotension first-degree relatives of type 2 diabetes mellitus

• Main Authors: Purnamasari D, Abdaly MS, Azizi MS, Wijaya IP, Nugroho P
• Format: Article
• Language: English
• Published: Dove Medical Press 2019-05-01
• Series: Vascular Health and Risk Management
• Subjects: First-degree relatives; type 2 diabetes mellitus; subclinical atherosclerosis; carotid intima-media thickness.
• Online Access: https://www.dovepress.com/carotid-intima-media-thickness-among-normoglycemia-and-normotension-fi-peer-reviewed-article-VHRM

Dyah Purnamasari,1 Muhammad Syah Abdaly,2 Mohamad Syahrir Azizi,3 Ika Prasetya Wijaya,3 Pringgodigdo Nugroho41Division of Endocrinology, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; 2Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; 3Division of Cardiology, Departement of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; 4Division of Nephrology, Departement of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, IndonesiaIntroduction: Theoretically, first-degree relatives (FDRs) of type 2 diabetes mellitus (T2DM) are predisposed to have earlier and more severe atherosclerosis than non-FDR due to hereditary insulin resistance. A previous study reported that atherosclerotic plaques were found in 45.2% of young adults FDR of T2DM, but the study did not include non-FDR as control group. The aim of this study was to compare subclinical atherosclerosis (carotid intima-media thickness, CIMT) between FDR of T2DM and non-FDR.Method: This was a cross-sectional study involving 16 FDR subjects and 16 age-sex matched non-FDR subjects, aged 19–40 years, with normal glucose tolerance and no hypertension. Collected data included demographic characteristic, anthropometric measurement (BMI and waist circumference), laboratory analysis (fasting blood glucose, HbA1c, lipid profile), and CIMT examination (using B-mode ultrasound).Results: The mean of CIMT in the FDR group was higher than that in the non-FDR group (0.44 mm vs 0.38 mm, p=0.005). After adjusting for waist circumference, BMI, low-density lipoprotein cholesterol, and triglyceride, CIMT maintained significant difference between FDR and non-FDR subjects. BMI and waist circumference showed moderate correlation with CIMT.Conclusion: CIMT in young adult FDR of T2DM is thicker than that in age-and sex-matched non-FDR population.Keywords: first-degree relatives, type 2 diabetes mellitus, subclinical atherosclerosis, carotid intima-media thickness