Th17 Cells in Immunity and Autoimmunity

Th17 Cells in Immunity and Autoimmunity

Th17 and IL-17 play important roles in the clearance of extracellular bacterial and fungal infections. However, strong evidence also implicates the Th17 lineage in several autoimmune disorders including multiple sclerosis, psoriasis, rheumatoid arthritis, inflammatory bowel disease, systemic lupus e...

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Main Authors: Simone Kennedy Bedoya, Brandon Lam, Kenneth Lau, Joseph Larkin
Format: Article
Language:English
Published: Hindawi Limited 2013-01-01
Series:Clinical and Developmental Immunology
Online Access:http://dx.doi.org/10.1155/2013/986789
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spelling doaj-d0725a7792134a4e89d65292b8f88b882020-11-24T21:06:37ZengHindawi LimitedClinical and Developmental Immunology1740-25221740-25302013-01-01201310.1155/2013/986789986789Th17 Cells in Immunity and AutoimmunitySimone Kennedy Bedoya0Brandon Lam1Kenneth Lau2Joseph Larkin3Department of Microbiology and Cell Science, University of Florida, P.O. Box 110700, Museum Road Building 981, Gainesville, FL 32611, USADepartment of Microbiology and Cell Science, University of Florida, P.O. Box 110700, Museum Road Building 981, Gainesville, FL 32611, USADepartment of Microbiology and Cell Science, University of Florida, P.O. Box 110700, Museum Road Building 981, Gainesville, FL 32611, USADepartment of Microbiology and Cell Science, University of Florida, P.O. Box 110700, Museum Road Building 981, Gainesville, FL 32611, USATh17 and IL-17 play important roles in the clearance of extracellular bacterial and fungal infections. However, strong evidence also implicates the Th17 lineage in several autoimmune disorders including multiple sclerosis, psoriasis, rheumatoid arthritis, inflammatory bowel disease, systemic lupus erythematosus, and asthma. The Th17 subset has also been connected with type I diabetes, although whether it plays a role in the pathogenicity of or protection from the disease remains a controversial issue. In this review we have provided a comprehensive overview of Th17 pathogenicity and function, including novel evidence for a protective role of Th17 cells in conjunction with the microbiota gut flora in T1D onset and progression.http://dx.doi.org/10.1155/2013/986789
collection DOAJ
language English
format Article
sources DOAJ
author Simone Kennedy Bedoya
Brandon Lam
Kenneth Lau
Joseph Larkin
spellingShingle Simone Kennedy Bedoya
Brandon Lam
Kenneth Lau
Joseph Larkin
Th17 Cells in Immunity and Autoimmunity
Clinical and Developmental Immunology
author_facet Simone Kennedy Bedoya
Brandon Lam
Kenneth Lau
Joseph Larkin
author_sort Simone Kennedy Bedoya
title Th17 Cells in Immunity and Autoimmunity
title_short Th17 Cells in Immunity and Autoimmunity
title_full Th17 Cells in Immunity and Autoimmunity
title_fullStr Th17 Cells in Immunity and Autoimmunity
title_full_unstemmed Th17 Cells in Immunity and Autoimmunity
title_sort th17 cells in immunity and autoimmunity
publisher Hindawi Limited
series Clinical and Developmental Immunology
issn 1740-2522
1740-2530
publishDate 2013-01-01
description Th17 and IL-17 play important roles in the clearance of extracellular bacterial and fungal infections. However, strong evidence also implicates the Th17 lineage in several autoimmune disorders including multiple sclerosis, psoriasis, rheumatoid arthritis, inflammatory bowel disease, systemic lupus erythematosus, and asthma. The Th17 subset has also been connected with type I diabetes, although whether it plays a role in the pathogenicity of or protection from the disease remains a controversial issue. In this review we have provided a comprehensive overview of Th17 pathogenicity and function, including novel evidence for a protective role of Th17 cells in conjunction with the microbiota gut flora in T1D onset and progression.
url http://dx.doi.org/10.1155/2013/986789
work_keys_str_mv AT simonekennedybedoya th17cellsinimmunityandautoimmunity
AT brandonlam th17cellsinimmunityandautoimmunity
AT kennethlau th17cellsinimmunityandautoimmunity
AT josephlarkin th17cellsinimmunityandautoimmunity
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