Homotypic Cell Cannibalism and Cannibalism Index-A Four Year Study in Inltrating Ductal Carcinoma Breast

• Main Authors: Alok Mohan, Pradeep Kr. Sharma, R.K. Thakral
• Format: Article
• Language: English
• Published: Krishna Institute of Medical Sciences University 2016-01-01
• Series: Journal of Krishna Institute of Medical Sciences University
• Subjects: Cytology; Carcinoma; Cannibalism Index; Breast; Malignancy
• Online Access: http://www.jkimsu.com/jkimsu-vol5no1/JKIMSU,%20Vol.%205,%20No.%201,%20Jan-March%202016%20Page%2061-67.pdf
• ISSN: 2231-4261; 2231-4261

Background: Homotypic cell cannibalism is a hallmark of malignant lesions. It serves as an emerging indicator of both the anaplastic grade and invasiveness. Aim and Objectives: The present study was conducted to correlate tumour cytological grade with the incidences of cell cannibalism. Material and Methods: Three stained smears per case were submitted for cytological grading. The smears were then submitted for visually counting the number of examples of cell cannibalism and the cannibalism index was calculated. Results: Seventy cytological diagnosed cases of breast malignancies were assessed for the presence of cell cannibalism. The results were correlated with the cytological grade of carcinoma. The study revealed that cell cannibalism was encountered in 68.57% cases of breast carcinoma. 44.4% of grade I, 71.4% of grade II and 100% of grade III tumours grade. It was observed that grade I tumours had mean cannibalism per smear of 1.62/1000 tumour cells smear, grade II mean cannibalism per smear of 2.50/ 1000 tumour cells and grade III mean cannibalism per smear 4.90/1000 tumour cells. Tumour diathesis and metastasis were also found more in cannibalism positive cases. Conclusion: The phenomenon of cell cannibalism was encountered more in high grade tumours. Thus it can be designated as an emerging marker of anaplasia and aggressive tumour behaviour