Epistasis between COMT and MTHFR in maternal-fetal dyads increases risk for preeclampsia.

Epistasis between COMT and MTHFR in maternal-fetal dyads increases risk for preeclampsia.

Preeclampsia is a leading cause of perinatal morbidity and mortality. This disorder is thought to be multifactorial in origin, with multiple genes, environmental and social factors, contributing to disease. One proposed mechanism is placental hypoxia-driven imbalances in angiogenic and anti-angiogen...

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Bibliographic Details
Main Authors: Lori D Hill, Timothy P York, Juan P Kusanovic, Ricardo Gomez, Lindon J Eaves, Roberto Romero, Jerome F Strauss
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3031618?pdf=render

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