Programmed suppression of oxidative phosphorylation and mitochondrial function by gestational alcohol exposure correlate with widespread increases in H3K9me2 that do not suppress transcription

Abstract Background A critical question emerging in the field of developmental toxicology is whether alterations in chromatin structure induced by toxicant exposure control patterns of gene expression or, instead, are structural changes that are part of a nuclear stress response. Previously, we used...

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Bibliographic Details
Main Authors: Richard C. Chang, Kara N. Thomas, Nicole A. Mehta, Kylee J. Veazey, Scott E. Parnell, Michael C. Golding
Format: Article
Language:English
Published: BMC 2021-06-01
Series:Epigenetics & Chromatin
Subjects:
Online Access:https://doi.org/10.1186/s13072-021-00403-w